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Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9
The Rag GTPases (Rags) recruit mTORC1 to the lysosomal membrane in response to nutrients, where it is then activated in response to energy and growth factor availability. The lysosomal folliculin (FLCN) complex (LFC) consists of the inactive Rag dimer, the pentameric scaffold Ragulator, and the FLCN...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7644641/ https://ncbi.nlm.nih.gov/pubmed/32868926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0490-9 |
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