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Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

The mechanistic target of rapamycin complex 1 (mTORC1) growth pathway detects nutrients through a variety of sensors and regulators that converge on the Rag GTPases, which form heterodimers consisting of RagA or RagB tightly bound to RagC or RagD and control the subcellular localization of mTORC1. T...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Shen, Kuang, Sabatini, David M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156610/
https://ncbi.nlm.nih.gov/pubmed/30181260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811727115
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