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Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
The mechanistic target of rapamycin complex 1 (mTORC1) growth pathway detects nutrients through a variety of sensors and regulators that converge on the Rag GTPases, which form heterodimers consisting of RagA or RagB tightly bound to RagC or RagD and control the subcellular localization of mTORC1. T...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6156610/ https://ncbi.nlm.nih.gov/pubmed/30181260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811727115 |
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