Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice

Bronchopulmonary dysplasia (BPD) is a chronic disease of preterm babies with poor clinical outcomes. Nrf2 transcription factor is crucial for cytoprotective response, whereas Keap1—an endogenous inhibitor of Nrf2 signaling—dampens these protective responses. Nrf2-sufficient (wild type) newborn mice...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Tamatam, Chandra M., Reddy, Narsa M., Potteti, Haranatha R., Ankireddy, Aparna, Noone, Patrick M., Yamamoto, Masayuki, Kensler, Thomas W., Reddy, Sekhar P.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642393/
https://ncbi.nlm.nih.gov/pubmed/33149211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75834-8
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