PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice

Lung epithelial and endothelial cell death accompanied by inflammation contributes to hyperoxia-induced acute lung injury (ALI). Impaired resolution of ALI can promote and/or perpetuate lung pathogenesis, including fibrosis. Previously, we have shown that the transcription factor Nrf2 induces cytopr...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Reddy, Narsa M., Potteti, Haranatha R., Vegiraju, Suryanarayana, Chen, Hsin-Jou, Tamatam, Chandra Mohan, Reddy, Sekhar P.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467869/
https://ncbi.nlm.nih.gov/pubmed/26075390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129676
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