Sirtuin 1 Promotes Hyperoxia-Induced Lung Epithelial Cell Death Independent of NF-E2–Related Factor 2 Activation

Lung epithelial cell damage accompanied by death is a cardinal feature of toxicant- and prooxidant-induced acute lung injury. The transcription factor nuclear factor (erythroid-derived 2)-like 2 (NEF2L2 or NRF2) activates several antioxidant enzymes (AOEs) and prosurvival genes in response to oxidan...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Potteti, Haranatha R., Rajasekaran, Subbiah, Rajamohan, Senthilkumar B., Tamatam, Chandramohan R., Reddy, Narsa M., Reddy, Sekhar P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942191/
https://ncbi.nlm.nih.gov/pubmed/26465873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0056OC
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