An engineered T cell receptor variant realizes the limits of functional binding modes

T cell receptors (TCRs) orchestrate cellular immunity by recognizing peptides presented by a range of major histocompatibility complex (MHC) proteins. Naturally occurring TCRs bind the composite peptide/MHC surface, recognizing peptides that are structurally and chemically compatible with the TCR bi...

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Pubblicato in:Biochemistry
Autori principali: Singh, Nishant K., Alonso, Jesus A., Harris, Daniel T., Anderson, Scott D., Ma, Jiaqi, Hellman, Lance M., Rosenberg, Aaron M., Kolawole, Elizabeth M., Evavold, Brian D., Kranz, David M., Baker, Brian M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642186/
https://ncbi.nlm.nih.gov/pubmed/33074657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00689
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