An engineered T cell receptor variant realizes the limits of functional binding modes

T cell receptors (TCRs) orchestrate cellular immunity by recognizing peptides presented by a range of major histocompatibility complex (MHC) proteins. Naturally occurring TCRs bind the composite peptide/MHC surface, recognizing peptides that are structurally and chemically compatible with the TCR bi...

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Udgivet i:Biochemistry
Main Authors: Singh, Nishant K., Alonso, Jesus A., Harris, Daniel T., Anderson, Scott D., Ma, Jiaqi, Hellman, Lance M., Rosenberg, Aaron M., Kolawole, Elizabeth M., Evavold, Brian D., Kranz, David M., Baker, Brian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642186/
https://ncbi.nlm.nih.gov/pubmed/33074657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00689
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