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An engineered switch in T cell receptor specificity leads to an unusual but functional binding geometry
Utilizing a diverse binding site, T cell receptors (TCRs) specifically recognize a composite ligand comprised of a foreign peptide and a major histocompatibility complex protein (MHC). To help understand the determinants of TCR specificity, we studied a parental and engineered receptor whose peptide...
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| Yayımlandı: | Structure |
|---|---|
| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4938795/ https://ncbi.nlm.nih.gov/pubmed/27238970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.04.011 |
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