Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble ACE2 is a therapeutic candidate that neutralizes infection by acting as a decoy. By using deep mutagenesis, mutations in ACE...

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Bibliografiske detaljer
Udgivet i:Science
Main Authors: Chan, Kui K., Dorosky, Danielle, Sharma, Preeti, Abbasi, Shawn A., Dye, John M., Kranz, David M., Herbert, Andrew S., Procko, Erik
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574912/
https://ncbi.nlm.nih.gov/pubmed/32753553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc0870
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