Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble ACE2 is a therapeutic candidate that neutralizes infection by acting as a decoy. By using deep mutagenesis, mutations in ACE...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Science
Autori principali: Chan, Kui K., Dorosky, Danielle, Sharma, Preeti, Abbasi, Shawn A., Dye, John M., Kranz, David M., Herbert, Andrew S., Procko, Erik
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
Soggetti:
Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574912/
https://ncbi.nlm.nih.gov/pubmed/32753553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc0870
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi