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An engineered switch in T cell receptor specificity leads to an unusual but functional binding geometry

Utilizing a diverse binding site, T cell receptors (TCRs) specifically recognize a composite ligand comprised of a foreign peptide and a major histocompatibility complex protein (MHC). To help understand the determinants of TCR specificity, we studied a parental and engineered receptor whose peptide...

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Bibliografiske detaljer
Udgivet i:Structure
Main Authors: Harris, Daniel T., Singh, Nishant K., Cai, Qi, Smith, Sheena N., Vander Kooi, Craig, Procko, Erik, Kranz, David M., Baker, Brian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938795/
https://ncbi.nlm.nih.gov/pubmed/27238970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.04.011
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