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MHC Bias by T Cell Receptors: Genetic Evidence for MHC and TCR Co-Evolution

MHC restriction is a fundamental tenet of T cell biology, but the underlying mechanisms have remained controversial. The extent to which T cell receptors are biased towards MHC proteins in particular has been widely discussed. In a recent paper, Sharon et al. report direct evidence for co-evolution...

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Bibliographic Details
Published in:Trends Immunol
Main Authors: Baker, Brian M., Evavold, Brian D.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5208042/
https://ncbi.nlm.nih.gov/pubmed/27939452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2016.11.003
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