The kinetics of two dimensional TCR and pMHC interactions determine T cell responsiveness

The T cell receptor (TCR) interacts with peptide-major histocompatibility complexes (pMHC) to discriminate pathogens from self-antigens and trigger adaptive immune responses. Direct physical contact is required between the T cell and the antigen-presenting cell (APC) for cross-junctional binding whe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Huang, Jun, Zarnitsyna, Veronika I., Liu, Baoyu, Edwards, Lindsay J., Jiang, Ning, Evavold, Brian D., Zhu, Cheng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925443/
https://ncbi.nlm.nih.gov/pubmed/20357766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08944
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