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The kinetics of two dimensional TCR and pMHC interactions determine T cell responsiveness
The T cell receptor (TCR) interacts with peptide-major histocompatibility complexes (pMHC) to discriminate pathogens from self-antigens and trigger adaptive immune responses. Direct physical contact is required between the T cell and the antigen-presenting cell (APC) for cross-junctional binding whe...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2925443/ https://ncbi.nlm.nih.gov/pubmed/20357766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08944 |
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