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Antigen-specific TCR–pMHC catch bonds trigger signaling by fast accumulation of force-prolonged bond lifetimes
TCR–pMHC interactions initiate adaptive immune responses, but the mechanism of how such interactions under force induce T-cell signaling is unclear. We show that force prolongs lifetimes of single TCR–pMHC bonds for agonists (catch bonds) but shortens those for antagonists (slip bonds). Both magnitu...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4123688/ https://ncbi.nlm.nih.gov/pubmed/24725404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.02.053 |
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