TCR–pMHC bond conformation controls TCR ligand discrimination

A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζ receptors at the m...

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Detalles Bibliográficos
Publicado en:Cell Mol Immunol
Main Authors: Sasmal, Dibyendu K., Feng, Wei, Roy, Sobhan, Leung, Peter, He, Yanran, Cai, Chufan, Cao, Guoshuai, Lian, Huada, Qin, Jian, Hui, Enfu, Schreiber, Hans, Adams, Erin J., Huang, Jun
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052167/
https://ncbi.nlm.nih.gov/pubmed/31530899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0273-6
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