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Force-regulated in situ TCR–pMHC-II kinetics determine functions of CD4(+) T cells

We have recently shown that two-dimensional (2D) and force-regulated kinetics of TCR–pMHC-I interactions predict responses of CD8(+) T cells. To test whether these findings are applicable to CD4(+) T cells, we analyzed the in situ 3.L2 TCR–pMHC-II interactions for a well-characterized panel of alter...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Hong, Jinsung, Persaud, Stephen P., Horvath, Stephen, Allen, Paul M., Evavold, Brian D., Zhu, Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592802/
https://ncbi.nlm.nih.gov/pubmed/26336148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501407
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