Cryo-EM reveals unanchored M1-ubiquitin chain binding at hRpn11 of the 26S proteasome

The 26S proteasome is specialized for regulated protein degradation and formed by a dynamic regulatory particle (RP) that caps a hollow cylindrical core particle (CP) where substrates are proteolyzed. Its diverse substrates unify as proteasome targets by ubiquitination. We used cryogenic electron mi...

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Publicat a:Structure
Autors principals: Chen, Xiang, Dorris, Zachary, Shi, Dan, Huang, Rick K, Khant, Htet, Fox, Tara, de Val, Natalia, Williams, Dewight, Zhang, Ping, Walters, Kylie J
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642156/
https://ncbi.nlm.nih.gov/pubmed/32783951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.07.011
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