Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy

Colorectal cancer (CRC) is driven by mutations that activate canonical WNT/β-catenin signaling, but inhibiting WNT has significant on-target toxicity, and there are no approved therapies targeting dominant oncogenic drivers. We recently found that activating a β-catenin independent branch of WNT sig...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Hinze, Laura, Labrosse, Roxane, Degar, James, Han, Teng, Schatoff, Emma M., Schreek, Sabine, Karim, Salmaan, McGuckin, Connor, Sacher, Joshua R., Wagner, Florence, Stanulla, Martin, Yuan, Chen, Sicinska, Ewa, Giannakis, Marios, Ng, Kimmie, Dow, Lukas E., Gutierrez, Alejandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642035/
https://ncbi.nlm.nih.gov/pubmed/32703769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1472
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