Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute leukemias resistant to this enzyme. Wnt pathway activati...

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Vydáno v:Cancer Cell
Hlavní autoři: Hinze, Laura, Pfirrmann, Maren, Karim, Salmaan, Degar, James, McGuckin, Connor, Vinjamur, Divya, Sacher, Joshua, Stevenson, Kristen E., Neuberg, Donna S., Orellana, Esteban, Stanulla, Martin, Gregory, Richard I., Bauer, Daniel E., Wagner, Florence F., Stegmaier, Kimberly, Gutierrez, Alejandro
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541931/
https://ncbi.nlm.nih.gov/pubmed/30991026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.03.004
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