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ZNF410 represses fetal globin by singular control of CHD4
Known fetal hemoglobin (HbF) silencers have potential on-target liabilities for rational β-hemoglobinopathy therapeutic inhibition. Here through transcription factor (TF) CRISPR screening we identify ZNF410 as an HbF repressor. ZNF410 does not bind directly to the γ-globin genes but rather its chrom...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nat Genet |
|---|---|
| Prif Awduron: | , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2021
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8180380/ https://ncbi.nlm.nih.gov/pubmed/33859416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00843-w |
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