Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute leukemias resistant to this enzyme. Wnt pathway activati...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cancer Cell
Autors principals: Hinze, Laura, Pfirrmann, Maren, Karim, Salmaan, Degar, James, McGuckin, Connor, Vinjamur, Divya, Sacher, Joshua, Stevenson, Kristen E., Neuberg, Donna S., Orellana, Esteban, Stanulla, Martin, Gregory, Richard I., Bauer, Daniel E., Wagner, Florence F., Stegmaier, Kimberly, Gutierrez, Alejandro
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541931/
https://ncbi.nlm.nih.gov/pubmed/30991026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.03.004
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars