Epigenomic state transitions characterize tumor progression in mouse lung adenocarcinoma

Regulatory networks that maintain functional, differentiated cell states are often dysregulated in tumor development. Here, we use single-cell epigenomics to profile chromatin state transitions in a mouse model of lung adenocarcinoma (LUAD). We identify an epigenomic continuum representing loss of c...

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Udgivet i:Cancer Cell
Main Authors: LaFave, Lindsay M., Kartha, Vinay K., Ma, Sai, Meli, Kevin, Priore, Isabella Del, Lareau, Caleb, Naranjo, Santiago, Westcott, Peter, Duarte, Fabiana M., Sankar, Venkat, Chiang, Zachary, Brack, Alison, Law, Travis, Hauck, Haley, Okimoto, Annalisa, Regev, Aviv, Buenrostro, Jason D., Jacks, Tyler
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641015/
https://ncbi.nlm.nih.gov/pubmed/32707078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.06.006
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