Epigenomic state transitions characterize tumor progression in mouse lung adenocarcinoma

Regulatory networks that maintain functional, differentiated cell states are often dysregulated in tumor development. Here, we use single-cell epigenomics to profile chromatin state transitions in a mouse model of lung adenocarcinoma (LUAD). We identify an epigenomic continuum representing loss of c...

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發表在:Cancer Cell
Main Authors: LaFave, Lindsay M., Kartha, Vinay K., Ma, Sai, Meli, Kevin, Priore, Isabella Del, Lareau, Caleb, Naranjo, Santiago, Westcott, Peter, Duarte, Fabiana M., Sankar, Venkat, Chiang, Zachary, Brack, Alison, Law, Travis, Hauck, Haley, Okimoto, Annalisa, Regev, Aviv, Buenrostro, Jason D., Jacks, Tyler
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641015/
https://ncbi.nlm.nih.gov/pubmed/32707078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.06.006
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