Epigenomic state transitions characterize tumor progression in mouse lung adenocarcinoma

Regulatory networks that maintain functional, differentiated cell states are often dysregulated in tumor development. Here, we use single-cell epigenomics to profile chromatin state transitions in a mouse model of lung adenocarcinoma (LUAD). We identify an epigenomic continuum representing loss of c...

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Bibliografiska uppgifter
I publikationen:Cancer Cell
Huvudupphovsmän: LaFave, Lindsay M., Kartha, Vinay K., Ma, Sai, Meli, Kevin, Priore, Isabella Del, Lareau, Caleb, Naranjo, Santiago, Westcott, Peter, Duarte, Fabiana M., Sankar, Venkat, Chiang, Zachary, Brack, Alison, Law, Travis, Hauck, Haley, Okimoto, Annalisa, Regev, Aviv, Buenrostro, Jason D., Jacks, Tyler
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641015/
https://ncbi.nlm.nih.gov/pubmed/32707078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.06.006
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