Epigenomic state transitions characterize tumor progression in mouse lung adenocarcinoma

Regulatory networks that maintain functional, differentiated cell states are often dysregulated in tumor development. Here, we use single-cell epigenomics to profile chromatin state transitions in a mouse model of lung adenocarcinoma (LUAD). We identify an epigenomic continuum representing loss of c...

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Detaylı Bibliyografya
Yayımlandı:Cancer Cell
Asıl Yazarlar: LaFave, Lindsay M., Kartha, Vinay K., Ma, Sai, Meli, Kevin, Priore, Isabella Del, Lareau, Caleb, Naranjo, Santiago, Westcott, Peter, Duarte, Fabiana M., Sankar, Venkat, Chiang, Zachary, Brack, Alison, Law, Travis, Hauck, Haley, Okimoto, Annalisa, Regev, Aviv, Buenrostro, Jason D., Jacks, Tyler
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641015/
https://ncbi.nlm.nih.gov/pubmed/32707078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.06.006
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