Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death

Expression of the transcription factor brachyury (TBXT) is normally restricted to the embryo and its silencing is epigenetically regulated. TBXT promotes mesenchymal transition in a subset of common carcinomas, and in chordoma, a rare cancer showing notochordal differentiation, TBXT acts as a putati...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Cottone, Lucia, Cribbs, Adam P, Khandelwal, Garima, Wells, Graham, Ligammari, Lorena, Philpott, Martin, Tumber, Anthony, Lombard, Patrick, Hookway, Edward S, Szommer, Tamas, Johansson, Catrine, Brennan, Paul E, Pillay, Nischalan, Jenner, Richard G, Oppermann, Udo, Flanagan, Adrienne M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616956/
https://ncbi.nlm.nih.gov/pubmed/32855205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1387
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