Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death

Expression of the transcription factor brachyury (TBXT) is normally restricted to the embryo and its silencing is epigenetically regulated. TBXT promotes mesenchymal transition in a subset of common carcinomas, and in chordoma, a rare cancer showing notochordal differentiation, TBXT acts as a putati...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Cottone, Lucia, Cribbs, Adam P, Khandelwal, Garima, Wells, Graham, Ligammari, Lorena, Philpott, Martin, Tumber, Anthony, Lombard, Patrick, Hookway, Edward S, Szommer, Tamas, Johansson, Catrine, Brennan, Paul E, Pillay, Nischalan, Jenner, Richard G, Oppermann, Udo, Flanagan, Adrienne M
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616956/
https://ncbi.nlm.nih.gov/pubmed/32855205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1387
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