Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site

Immunotherapy advances have been hindered by difficulties in tracking the behaviors of lymphocytes following antigen signaling. Here we assessed the behavior of T cells active within tumors through the development of the antigen receptor signaling reporter (AgRSR) mouse, fate mapping lymphocytes res...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Immunol
Hlavní autoři: Takahashi, Munetomo, So, Tsz Y., Chamberlain-Evans, Vitalina, Hughes, Robert, Yam-Puc, Juan Carlos, Kania, Katarzyna, Ruhle, Michelle, Mann, Tiffeney, Schuijs, Martijn J., Coupland, Paul, Naisbitt, Dean, Halim, Timotheus Y.F., Lyons, Paul A., Lio, Pietro, Roychoudhuri, Rahul, Okkenhaug, Klaus, Adams, David J., Smith, Ken G.C., Jodrell, Duncan I., Chapman, Michael A., Thaventhiran, James E. D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2024
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616235/
https://ncbi.nlm.nih.gov/pubmed/38787961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.ade2094
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky