Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site

Immunotherapy advances have been hindered by difficulties in tracking the behaviors of lymphocytes following antigen signaling. Here we assessed the behavior of T cells active within tumors through the development of the antigen receptor signaling reporter (AgRSR) mouse, fate mapping lymphocytes res...

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Udgivet i:Sci Immunol
Main Authors: Takahashi, Munetomo, So, Tsz Y., Chamberlain-Evans, Vitalina, Hughes, Robert, Yam-Puc, Juan Carlos, Kania, Katarzyna, Ruhle, Michelle, Mann, Tiffeney, Schuijs, Martijn J., Coupland, Paul, Naisbitt, Dean, Halim, Timotheus Y.F., Lyons, Paul A., Lio, Pietro, Roychoudhuri, Rahul, Okkenhaug, Klaus, Adams, David J., Smith, Ken G.C., Jodrell, Duncan I., Chapman, Michael A., Thaventhiran, James E. D.
Format: Artigo
Sprog:Inglês
Udgivet: 2024
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616235/
https://ncbi.nlm.nih.gov/pubmed/38787961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.ade2094
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