Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site

Immunotherapy advances have been hindered by difficulties in tracking the behaviors of lymphocytes following antigen signaling. Here we assessed the behavior of T cells active within tumors through the development of the antigen receptor signaling reporter (AgRSR) mouse, fate mapping lymphocytes res...

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Pubblicato in:Sci Immunol
Autori principali: Takahashi, Munetomo, So, Tsz Y., Chamberlain-Evans, Vitalina, Hughes, Robert, Yam-Puc, Juan Carlos, Kania, Katarzyna, Ruhle, Michelle, Mann, Tiffeney, Schuijs, Martijn J., Coupland, Paul, Naisbitt, Dean, Halim, Timotheus Y.F., Lyons, Paul A., Lio, Pietro, Roychoudhuri, Rahul, Okkenhaug, Klaus, Adams, David J., Smith, Ken G.C., Jodrell, Duncan I., Chapman, Michael A., Thaventhiran, James E. D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2024
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616235/
https://ncbi.nlm.nih.gov/pubmed/38787961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.ade2094
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