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Oncogenic PI3Kα promotes multipotency in breast epithelial cells
The phosphoinositide 3-kinase (PI3K) signaling pathway is among the most frequently altered in cancer. Two studies show that a mutated oncogenic PI3Kα, commonly found in breast cancer, leads to de-differentiation or destabilization of luminal and basal epithelial lineages, which in turn leads to inc...
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| Publicat a: | Sci Signal |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4637986/ https://ncbi.nlm.nih.gov/pubmed/26535006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad5856 |
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