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Oncogenic PI3Kα promotes multipotency in breast epithelial cells
The phosphoinositide 3-kinase (PI3K) signaling pathway is among the most frequently altered in cancer. Two studies show that a mutated oncogenic PI3Kα, commonly found in breast cancer, leads to de-differentiation or destabilization of luminal and basal epithelial lineages, which in turn leads to inc...
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| Publicado no: | Sci Signal |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4637986/ https://ncbi.nlm.nih.gov/pubmed/26535006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad5856 |
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