Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M(1) Muscarinic Acetylcholine Receptor

This study investigated the structure-activity relationships of 4-phenylpyridin-2-one and 6-phenylpyrimidin-4-one muscarinic M(1) acetylcholine receptor (M(1) mAChRs) positive allosteric modulators (PAMs). The presented series focuses on modifications to the core and top motif of the reported leads,...

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Publicado no:ChemMedChem
Main Authors: Jörg, Manuela, Khajehali, Elham, van der Westhuizen, Emma T., Choy, K. H. Christopher, Shackleford, David, Tobin, Andrew B., Sexton, Patrick M., Valant, Celine, Capuano, Ben, Christopoulos, Arthur, Scammells, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616174/
https://ncbi.nlm.nih.gov/pubmed/32851779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000540
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