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Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility
CRISPR-Cas9 genome engineering is a powerful technology for correcting genetic diseases. However, the targeting range of Cas9 proteins is limited by their requirement for a protospacer adjacent motif (PAM) and in vivo delivery is challenging due to their large size. Here, we use phage-assisted conti...
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| Publicado en: | Nat Chem Biol |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2024
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7616171/ https://ncbi.nlm.nih.gov/pubmed/37735239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-023-01427-x |
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