Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors

The complement system is a critical part of our innate immune response, and the terminal products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and pathophysiological responses primarily via two GPCRs, C3aR and C5aR1. However, the molecular mechanism of ligand recognition, a...

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Published in:Cell
Main Authors: Yadav, Manish K., Maharana, Jagannath, Yadav, Ravi, Saha, Shirsha, Sarma, Parishmita, Soni, Chahat, Singh, Vinay, Saha, Sayantan, Ganguly, Manisankar, Li, Xaria X., Mohapatra, Samanwita, Mishra, Sudha, Khant, Htet A., Chami, Mohamed, Woodruff, Trent M., Banerjee, Ramanuj, Shukla, Arun K., Gati, Cornelius
Format: Artigo
Language:Inglês
Published: 2023
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615941/
https://ncbi.nlm.nih.gov/pubmed/37852260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2023.09.020
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