Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice

OBJECTIVE: Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in skeletal muscle (SM), research in this area is limited. We hypothesized that LAL may play an impor...

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Bibliografiska uppgifter
I publikationen:Mol Metab
Huvudupphovsmän: Akhmetshina, Alena, Bianco, Valentina, Bradić, Ivan, Korbelius, Melanie, Pirchheim, Anita, Kuentzel, Katharina B., Eichmann, Thomas O., Hinteregger, Helga, Kolb, Dagmar, Habisch, Hansjoerg, Liesinger, Laura, Madl, Tobias, Sattler, Wolfgang, Radović, Branislav, Sedej, Simon, Birner-Gruenberger, Ruth, Vujić, Nemanja, Kratky, Dagmar
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2023
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615526/
https://ncbi.nlm.nih.gov/pubmed/38160938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2023.101869
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