Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice

OBJECTIVE: Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in skeletal muscle (SM), research in this area is limited. We hypothesized that LAL may play an impor...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Akhmetshina, Alena, Bianco, Valentina, Bradić, Ivan, Korbelius, Melanie, Pirchheim, Anita, Kuentzel, Katharina B., Eichmann, Thomas O., Hinteregger, Helga, Kolb, Dagmar, Habisch, Hansjoerg, Liesinger, Laura, Madl, Tobias, Sattler, Wolfgang, Radović, Branislav, Sedej, Simon, Birner-Gruenberger, Ruth, Vujić, Nemanja, Kratky, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615526/
https://ncbi.nlm.nih.gov/pubmed/38160938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2023.101869
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