Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice

OBJECTIVE: Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in skeletal muscle (SM), research in this area is limited. We hypothesized that LAL may play an impor...

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Bibliografske podrobnosti
izdano v:Mol Metab
Main Authors: Akhmetshina, Alena, Bianco, Valentina, Bradić, Ivan, Korbelius, Melanie, Pirchheim, Anita, Kuentzel, Katharina B., Eichmann, Thomas O., Hinteregger, Helga, Kolb, Dagmar, Habisch, Hansjoerg, Liesinger, Laura, Madl, Tobias, Sattler, Wolfgang, Radović, Branislav, Sedej, Simon, Birner-Gruenberger, Ruth, Vujić, Nemanja, Kratky, Dagmar
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2023
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615526/
https://ncbi.nlm.nih.gov/pubmed/38160938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2023.101869
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