Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice

OBJECTIVE: Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in skeletal muscle (SM), research in this area is limited. We hypothesized that LAL may play an impor...

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Détails bibliographiques
Publié dans:Mol Metab
Auteurs principaux: Akhmetshina, Alena, Bianco, Valentina, Bradić, Ivan, Korbelius, Melanie, Pirchheim, Anita, Kuentzel, Katharina B., Eichmann, Thomas O., Hinteregger, Helga, Kolb, Dagmar, Habisch, Hansjoerg, Liesinger, Laura, Madl, Tobias, Sattler, Wolfgang, Radović, Branislav, Sedej, Simon, Birner-Gruenberger, Ruth, Vujić, Nemanja, Kratky, Dagmar
Format: Artigo
Langue:Inglês
Publié: Elsevier 2023
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615526/
https://ncbi.nlm.nih.gov/pubmed/38160938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2023.101869
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