Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden

BACKGROUND AND AIMS: Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is the rate-limiting enzyme catalyzing the final step of triglyceride synthesis by esterifying a diglyceride with a fatty acid. We have previously shown that apolipoprotein E-knockout (ApoE (−/−)) mice lacking Dgat1 have reduced...

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Pubblicato in:Atherosclerosis
Autori principali: Vujić, Nemanja, Korbelius, Melanie, Sachdev, Vinay, Rainer, Silvia, Zimmer, Andreas, Huber, Anton, Radović, Branislav, Kratky, Dagmar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116265/
https://ncbi.nlm.nih.gov/pubmed/32882484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2020.07.030
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