Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice

Triacylglycerols (TG) are the major storage molecules of metabolic energy and fatty acids in several tissues. The final step in TG biosynthesis is catalyzed by acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes. Lack of whole body DGAT1 is associated with reduced lipid-induced inflammation. Sinc...

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Main Authors: Chandak, Prakash G., Obrowsky, Sascha, Radovic, Branislav, Doddapattar, Prakash, Aflaki, Elma, Kratzer, Adelheid, Doshi, Lalit S., Povoden, Silvia, Ahammer, Helmut, Hoefler, Gerald, Levak-Frank, Sanja, Kratky, Dagmar
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Pub. Co 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223411/
https://ncbi.nlm.nih.gov/pubmed/21924378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2011.08.010
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