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Molecular determinants of ligand efficacy and potency in GPCR signaling
G protein-coupled receptors bind to extracellular ligands and drugs and modulate intracellular responses through conformational changes. Despite their importance as drug targets, the molecular origins of pharmacological properties such as efficacy (maximum signaling response) and potency (the ligand...
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| Veröffentlicht in: | Science |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2023
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7615523/ https://ncbi.nlm.nih.gov/pubmed/38127743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.adh1859 |
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