ロード中...

Meiotic DNA breaks drive multifaceted mutagenesis in the human germline

Meiotic recombination commences with hundreds of programmed DNA breaks, however the degree to which they are accurately repaired remains poorly understood. We report that meiotic break repair is 8-fold more mutagenic for single-base substitutions than was previously understood, leading to de novo mu...

詳細記述

保存先:
書誌詳細
出版年:Science
主要な著者: Hinch, Robert, Donnelly, Peter, Hinch, Anjali Gupta
フォーマット: Artigo
言語:Inglês
出版事項: 2023
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615360/
https://ncbi.nlm.nih.gov/pubmed/38033082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.adh2531
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!