ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

During meiosis, homologous chromosomes pair and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, double-strand breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and deposits H3K4me3 and H3K36me3. However, no protein(s) recognising...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Wells, Daniel, Bitoun, Emmanuelle, Moralli, Daniela, Zhang, Gang, Hinch, Anjali, Jankowska, Julia, Donnelly, Peter, Green, Catherine, Myers, Simon R
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2020
Предметы:
Genetics and Genomics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494361/
https://ncbi.nlm.nih.gov/pubmed/32744506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53392
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