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ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

During meiosis, homologous chromosomes pair and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, double-strand breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and deposits H3K4me3 and H3K36me3. However, no protein(s) recognising...

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書目詳細資料
發表在:eLife
Main Authors: Wells, Daniel, Bitoun, Emmanuelle, Moralli, Daniela, Zhang, Gang, Hinch, Anjali, Jankowska, Julia, Donnelly, Peter, Green, Catherine, Myers, Simon R
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494361/
https://ncbi.nlm.nih.gov/pubmed/32744506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53392
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