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Meiotic DNA breaks drive multifaceted mutagenesis in the human germline
Meiotic recombination commences with hundreds of programmed DNA breaks, however the degree to which they are accurately repaired remains poorly understood. We report that meiotic break repair is 8-fold more mutagenic for single-base substitutions than was previously understood, leading to de novo mu...
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| Publicado en: | Science |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7615360/ https://ncbi.nlm.nih.gov/pubmed/38033082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.adh2531 |
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