PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection

Disruption of cellular activities by pathogen virulence factors can trigger innate immune responses. Interferon-gamma (IFNγ)-inducible antimicrobial factors, such as the guanylate binding proteins (GBPs), promote cell-intrinsic defense by attacking intracellular pathogens and by inducing programmed...

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Veröffentlicht in:Science
Hauptverfasser: Fisch, Daniel, Pfleiderer, Moritz M, Anastasakou, Eleni, Mackie, Gillian M, Wendt, Fabian, Liu, Xiangyang, Clough, Barbara, Lara-Reyna, Samuel, Encheva, Vesela, Snijders, Ambrosius P, Bando, Hironori, Yamamoto, Masahiro, Beggs, Andrew D, Mercer, Jason, Shenoy, Avinash R, Wollscheid, Bernd, Maslowski, Kendle M, Galej, Wojtek P, Frickel, Eva-Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2023
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615196/
https://ncbi.nlm.nih.gov/pubmed/37797010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.adg2253
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