Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

Interferon-inducible guanylate-binding proteins (GBPs) promote cell-intrinsic defense through host cell death. GBPs target pathogens and pathogen-containing vacuoles and promote membrane disruption for release of microbial molecules that activate inflammasomes. GBP1 mediates pyroptosis or atypical a...

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Publicado en:Cell Rep
Main Authors: Fisch, Daniel, Clough, Barbara, Domart, Marie-Charlotte, Encheva, Vesela, Bando, Hironori, Snijders, Ambrosius P., Collinson, Lucy M., Yamamoto, Masahiro, Shenoy, Avinash R., Frickel, Eva-Maria
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7435695/
https://ncbi.nlm.nih.gov/pubmed/32783936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108008
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