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Human GBP1 is a microbe‐specific gatekeeper of macrophage apoptosis and pyroptosis

The guanylate binding protein (GBP) family of interferon‐inducible GTPases promotes antimicrobial immunity and cell death. During bacterial infection, multiple mouse Gbps, human GBP2, and GBP5 support the activation of caspase‐1‐containing inflammasome complexes or caspase‐4 which trigger pyroptosis...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Fisch, Daniel, Bando, Hironori, Clough, Barbara, Hornung, Veit, Yamamoto, Masahiro, Shenoy, Avinash R, Frickel, Eva‐Maria
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600649/
https://ncbi.nlm.nih.gov/pubmed/31268602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100926
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