Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4-NOT

Translation impacts mRNA stability and, in yeast, this is mediated by the Ccr4-Not deadenylation complex. The details of this process in mammals remain unclear. Here, we use cryoEM and crosslinking mass spectrometry to show that mammalian CCR4-NOT specifically recognizes ribosomes that are stalled d...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Absmeier, Eva, Chandrasekaran, Viswanathan, O’Reilly, Francis J, Stowell, James AW, Rappsilber, Juri, Passmore, Lori A
Format: Artigo
Sprog:Inglês
Udgivet: 2023
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615087/
https://ncbi.nlm.nih.gov/pubmed/37653243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-023-01075-8
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