mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases

Translation and decay of eukaryotic mRNAs is controlled by shortening of the poly(A) tail and release of the poly(A)-binding protein Pab1/PABP. The Ccr4-Not complex contains two exonucleases—Ccr4 and Caf1/Pop2—that mediate mRNA deadenylation. Here, using a fully reconstituted biochemical system with...

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Udgivet i:Mol Cell
Main Authors: Webster, Michael W., Chen, Ying-Hsin, Stowell, James A.W., Alhusaini, Najwa, Sweet, Thomas, Graveley, Brenton R., Coller, Jeff, Passmore, Lori A.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6024076/
https://ncbi.nlm.nih.gov/pubmed/29932902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.05.033
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