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Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4-NOT
Translation impacts mRNA stability and, in yeast, this is mediated by the Ccr4-Not deadenylation complex. The details of this process in mammals remain unclear. Here, we use cryoEM and crosslinking mass spectrometry to show that mammalian CCR4-NOT specifically recognizes ribosomes that are stalled d...
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| Опубликовано в: : | Nat Struct Mol Biol |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2023
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7615087/ https://ncbi.nlm.nih.gov/pubmed/37653243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-023-01075-8 |
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