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Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4-NOT
Translation impacts mRNA stability and, in yeast, this is mediated by the Ccr4-Not deadenylation complex. The details of this process in mammals remain unclear. Here, we use cryoEM and crosslinking mass spectrometry to show that mammalian CCR4-NOT specifically recognizes ribosomes that are stalled d...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2023
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7615087/ https://ncbi.nlm.nih.gov/pubmed/37653243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-023-01075-8 |
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